From the 30-share blue-chip pack, Larsen & Toubro, NTPC, Tata Steel, Power Grid, Tata Motors, Reliance Industries, ICICI Bank and Tata Consultancy Services were among the major laggards.
Titan, Maruti, Nestle and Bajaj Finserv were among the gainers.
In Asian markets, Seoul, Tokyo, and Hong Kong were trading sharply lower.
US markets ended lower on Friday.